Medically reviewed by Dr. Lauren Nawrocki, DNP, CRNP. Updated October 2026.
Quick answer: Testosterone injections can cause side effects such as acne, mood or energy changes, fluid retention, increased red blood cell counts, injection-site discomfort, reduced sperm production, and changes in sleep apnea symptoms. A clinician should review risks and monitoring before treatment.
At-a-Glance Guide
- Common effects after an injection: Injection-site soreness, acne or oily skin, changes in mood or energy, and fluid retention can occur. Symptoms that are severe, persistent, or rapidly worsening deserve a call to t
- Blood-count and cardiovascular monitoring: Testosterone can raise hematocrit in some patients. Follow-up may include blood pressure, blood counts, symptoms, and other testing based on age and medical history. Do not treat a
- Fertility and prostate considerations: Exogenous testosterone can suppress sperm production. Patients who may want biological children should discuss fertility-preserving options before starting. Prostate-related monito
- How to make treatment safer: Use only the prescribed product and dose, keep scheduled lab visits, report new symptoms, and never share injections. The safest plan is one that includes a clear reason for treatm
Common effects after an injection
Injection-site soreness, acne or oily skin, changes in mood or energy, and fluid retention can occur. Symptoms that are severe, persistent, or rapidly worsening deserve a call to the prescribing clinician.
Blood-count and cardiovascular monitoring
Testosterone can raise hematocrit in some patients. Follow-up may include blood pressure, blood counts, symptoms, and other testing based on age and medical history. Do not treat a new headache, chest pain, shortness of breath, or weakness as a routine injection reaction.
Fertility and prostate considerations
Exogenous testosterone can suppress sperm production. Patients who may want biological children should discuss fertility-preserving options before starting. Prostate-related monitoring is also individualized.
How to make treatment safer
Use only the prescribed product and dose, keep scheduled lab visits, report new symptoms, and never share injections. The safest plan is one that includes a clear reason for treatment and a stop-or-adjust plan.
Helpful GRH Resources
testosterone therapy safety testosterone therapy benefits testosterone therapy follow-ups.
Frequently Asked Questions
Do testosterone shots hurt?
Some soreness or bruising can occur, but severe pain, redness, swelling, fever, or drainage should be evaluated.
Can testosterone injections cause infertility?
They can suppress sperm production, so fertility goals must be discussed before treatment.
How often are follow-up labs needed?
Timing depends on the product, dose, response, and medical history; the prescriber should set the schedule.
Sources and Next Steps
For a personalized discussion, contact Green Relief Health at 410-368-0420 or use the Green Relief Health consultation resources. This article is educational information and does not replace individualized medical advice.
